2-Chloro-5-(trifluoromethylthio)benzyl Alcohol

Base Information

• Chemical Name: 2-Chloro-5-(trifluoromethylthio)benzyl Alcohol
• CAS No.: 83975-69-3
• Molecular Formula: C₈H₆ClF₃OS
• Molecular Weight: 242.649
• Mol file: 83975-69-3.mol

Synonyms:2-Chloro-5-(trifluoromethylthio)benzyl Alcohol

Chemical Property of 2-Chloro-5-(trifluoromethylthio)benzyl Alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-Chloro-5-(trifluoromethylthio)benzyl Alcohol

There total 1 articles about 2-Chloro-5-(trifluoromethylthio)benzyl Alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-5-(trifluoromethylthio)benzyl Chloride (83975-68-2) → 2-Chloro-5-(trifluoromethylthio)benzyl Alcohol (83975-69-3)

Guidance literature:

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; potassium acetate; Yield given. Multistep reaction; 1) DMSO, 60 deg C, 5 h; 2) ethanol/water, reflux, 7 h;

DOI:10.1135/cccc19823114

Reference yield: 37.0%

2-Chloro-5-(trifluoromethylthio)benzyl Alcohol (83975-69-3) → 2-Chloro-5-(trifluoromethylthio)benzaldehyde (83975-70-6)

Guidance literature:

With potassium dichromate; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; at 15 - 20 ℃; for 4h;

DOI:10.1135/cccc19823114

Reference yield:

2-Chloro-5-(trifluoromethylthio)benzyl Alcohol (83975-69-3) → 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde (83975-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / K₂Cr₂O₇-H₂SO₄, triethylbenzylammonium chloride / CH₂Cl₂; H₂O / 4 h / 15 - 20 °C

2: 75 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C

With potassium dichromate; sodium hydroxide; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;

DOI:10.1135/cccc19823114

upstream raw materials:

2-Chloro-5-(trifluoromethylthio)benzyl Chloride

Downstream raw materials:

2-Chloro-5-(trifluoromethylthio)benzaldehyde

5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

[2-(2,5-Difluoro-phenylsulfanyl)-5-trifluoromethylsulfanyl-phenyl]-(1-methyl-piperidin-4-yl)-methanol