5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

Base Information

• Chemical Name: 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde
• CAS No.: 83975-71-7
• Molecular Formula: C₁₄H₇F₅OS₂
• Molecular Weight: 350.333
• Mol file: 83975-71-7.mol

Synonyms:5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

Chemical Property of 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

There total 4 articles about 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Chloro-5-(trifluoromethylthio)benzaldehyde (83975-70-6) + 2,5-Difluorothiophenol (77380-28-0) → 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde (83975-71-7)

Guidance literature:

With sodium hydroxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 5.5h;

DOI:10.1135/cccc19823114

Reference yield:

2,5-difluoroaniline (367-30-6) → 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde (83975-71-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 75 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C

With sodium hydroxide; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1135/cccc19823114

Reference yield:

2-Chloro-5-(trifluoromethylthio)benzyl Alcohol (83975-69-3) → 5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde (83975-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / K₂Cr₂O₇-H₂SO₄, triethylbenzylammonium chloride / CH₂Cl₂; H₂O / 4 h / 15 - 20 °C

2: 75 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C

With potassium dichromate; sodium hydroxide; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;

DOI:10.1135/cccc19823114

upstream raw materials:

2-Chloro-5-(trifluoromethylthio)benzaldehyde

2,5-Difluorothiophenol

2,5-difluoroaniline

2-Chloro-5-(trifluoromethylthio)benzyl Alcohol

Downstream raw materials:

[2-(2,5-Difluoro-phenylsulfanyl)-5-trifluoromethylsulfanyl-phenyl]-(1-methyl-piperidin-4-yl)-methanol