C₁₈H₁₃F₃N₄O₃

Base Information

Chemical Name:C₁₈H₁₃F₃N₄O₃
CAS No.:1590408-75-5
Molecular Formula:C₁₈H₁₃F₃N₄O₃
Molecular Weight:390.321
Hs Code.:

C<sub>18</sub>H<sub>13</sub>F<sub>3</sub>N<sub>4</sub>O<sub>3</sub>

Synonyms:C₁₈H₁₃F₃N₄O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₃F₃N₄O₃

Chemical Property:

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Technology Process of C₁₈H₁₃F₃N₄O₃

There total 8 articles about C₁₈H₁₃F₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1590410-70-0
C₁₄H₈BrF₃N₂O₃

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1590408-75-5
C₁₈H₁₃F₃N₄O₃

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; Reflux;

Reference yield:

: 1590410-65-3
2,3-Dimethoxy-4-aminopyridine

: 1590408-75-5
C₁₈H₁₃F₃N₄O₃

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / acetonitrile

2: hydrogen bromide / acetic acid

3: Reflux

4: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / Molecular sieve

5: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / Reflux

With pyridine; pyridine N-oxide; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; oxygen; copper diacetate; sodium carbonate; In 1,4-dioxane; dichloromethane; water; acetic acid; acetonitrile; 4: |Suzuki Coupling / 5: |Suzuki Coupling;

Reference yield:

: 52605-97-7
2,3-dimethoxypyridine

: 1590408-75-5
C₁₈H₁₃F₃N₄O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

1.2: 1 h / -78 - 0 °C

2.1: dihydrogen peroxide; formic acid / 0 - 20 °C

3.1: triethylamine / toluene / 0.5 h / Molecular sieve; Inert atmosphere; Reflux

3.2: Reflux

4.1: N-Bromosuccinimide / acetonitrile

5.1: hydrogen bromide / acetic acid

6.1: Reflux

7.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / Molecular sieve

8.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / Reflux

With pyridine; pyridine N-oxide; N-Bromosuccinimide; n-butyllithium; formic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; dihydrogen peroxide; oxygen; copper diacetate; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetic acid; toluene; acetonitrile; 7.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;