2,3-Dimethoxypyridine

Base Information

• Chemical Name: 2,3-Dimethoxypyridine
• CAS No.: 52605-97-7
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• European Community (EC) Number: 676-530-7
• DSSTox Substance ID: DTXSID50405309
• Nikkaji Number: J328.334H
• Wikidata: Q72468480
• Mol file: 52605-97-7.mol

Synonyms:2,3-Dimethoxypyridine;52605-97-7;PYRIDINE, 2,3-DIMETHOXY-;MFCD03095043;dimethoxypyridine;2,3-dimethoxy-pyridine;2,3-Dimethoxy Pyridine;SCHEMBL63365;DTXSID50405309;QHUHPERZCBUMRK-UHFFFAOYSA-N;AKOS006223401;AB13430;AC-9468;CS-W008190;AS-12415;SY038240;A7697;FT-0609685;W-202983;InChI=1/C7H9NO2/c1-9-6-4-3-5-8-7(6)10-2/h3-5H,1-2H

Chemical Property of 2,3-Dimethoxypyridine

Chemical Property:

• Appearance/Colour: Yellow Liquid
• Vapor Pressure: 1.25mmHg at 25°C
• Refractive Index: 1.5205
• Boiling Point: 179.8 °C at 760 mmHg
• PKA: 4.70±0.10(Predicted)
• Flash Point: 63.6 °C
• PSA: 31.35000
• Density: 1.064 g/cm³
• LogP: 1.09880
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=CC=C1)OC
• Uses: 2,3-Dimethoxypyridine (cas# 52605-97-7) is a compound useful in organic synthesis.

Technology Process of 2,3-Dimethoxypyridine

There total 8 articles about 2,3-Dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methanol (67-56-1) + 2-chloro-3-methoxypyridine (52605-96-6) → 2,3-dimethoxypyridine (52605-97-7)

Guidance literature:

With sodium methylate; at 80 ℃;

Reference yield: 75.0%

2-chloro-3-methoxypyridine (52605-96-6) + sodium methylate (124-41-4) → 2,3-dimethoxypyridine (52605-97-7)

Guidance literature:

DOI:10.1021/jo00100a017

Reference yield: 60.0%

2-bromo-3-methoxypyridine (24100-18-3) → 2,3-dimethoxypyridine (52605-97-7)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

DOI:10.1016/S0040-4020(01)96539-1

upstream raw materials:

2,3-dichloro-pyridine

sodium methylate

2-bromo-3-methoxypyridine

2-chloro-3-methoxypyridine

Downstream raw materials:

C₈H₉NO₄

C₁₄H₈BrF₃N₂O₃

C₁₈H₁₃F₃N₄O₃

2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine