Pharmakon1600-01501175

Base Information

• Chemical Name: Pharmakon1600-01501175
• CAS No.: 1524-88-5
• Molecular Formula: C24H33FO6
• Molecular Weight: 436.521
• Hs Code.: 2937220000
• NSC Number: 757869
• Mol file: 1524-88-5.mol

Synonyms:Spectrum_000403;Spectrum2_000976;Spectrum3_001464;Spectrum4_000427;Spectrum5_001767;BSPBio_002987;KBioGR_000754;KBioSS_000883;DivK1c_000169;SPECTRUM1501175;SPBio_001011;HMS500I11;KBio1_000169;KBio2_000883;KBio2_003451;KBio2_006019;KBio3_002487;NINDS_000169;HMS1921N11;HMS2092J13;Pharmakon1600-01501175;CCG-40194;NSC757869;IDI1_000169;NCGC00178359-01;PD062816;SBI-0051675.P002;AB00052236_02;SR-05000001778;SR-05000001778-1;BRD-A49765801-001-02-5;BRD-A49765801-001-03-3

Chemical Property of Pharmakon1600-01501175

Chemical Property:

• Vapor Pressure: 8.35E-16mmHg at 25°C
• Melting Point: 247-255°
• Refractive Index: 1.572
• Boiling Point: 578.75 °C at 760 mmHg
• PKA: 12.87±0.10(Predicted)
• Flash Point: 303.817 °C
• PSA: 93.06000
• Density: 1.314 g/cm³
• LogP: 2.49870
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Water Solubility.: 295mg/L(25 oC)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 436.22611693
• Heavy Atom Count: 31
• Complexity: 868

Purity/Quality:

99%, ^*data from raw suppliers

Flurandrenolide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1(OC2CC3C4CC(C5=CC(=O)CCC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C
• Isomeric SMILES: C[C@]12CCC(=O)C=C1[C@H](CC3C2[C@H](C[C@]4(C3C[C@@H]5[C@]4(OC(O5)(C)C)C(=O)CO)C)O)F
• Uses: Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid. antiinflammatory; Glucocorticoid; antipsoriatic.
• Indications: Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid.
• Therapeutic Function: Glucocorticoid, Antiinflammatory
• Biological Functions: Corticosteroids influence all tissues of the body and produce numerous and varying effects in cells. These steroids regulate carbohydrate, lipid, and protein biosynthesis and metabolism (glucocorticoid effects), and they influence water and electrolyte balance (mineralocorticoid effects). Cortisol is the most potent glucocorticoid secreted by the adrenal gland, and aldosterone is the most potent endogenous mineralocorticoid. Both naturally occurring glucocorticoids and related, semisynthetic analogues can be evaluated in terms of their ability to sustain life, to stimulate an increase in blood glucose concentrations and a deposition of liver glycogen, to decrease circulating eosinophils, and to cause thymus involution in adrenalectomized animals. In addition, corticosteroids can affect immune system functions, inflammatory responses, and cell growth. The primary physiologic function of glucocorticoids is to maintain blood glucose levels and, thus, ensure glucose-dependent processes critical to life, particularly brain functions. Cortisol and related steroids accomplish this by stimulating the formation of glucose, by diminishing glucose use by peripheral tissues, and by promoting glycogen synthesis in the liver to increase carbohydrate stores for later release of glucose.
• Clinical Use: Two major uses of glucocorticoids are in the treatment of rheumatoid diseases and allergic manifestations. Their use in the treatment of severe asthma is well documented, as is the utility of glucocorticoids in sepsis and acute respiratory distress syndrome. They are effective in the treatment of rheumatoid arthritis, acute rheumatic fever, bursitis, spontaneous hypoglycemia in children, gout, rheumatoid carditis, sprue, allergy (including contact dermatitis), and other conditions. The treatment of chronic rheumatic diseases and allergic conditions with glucocorticoids is symptomatic and continuous. Symptoms return after withdrawal of the drug.

Technology Process of Pharmakon1600-01501175

There total 7 articles about Pharmakon1600-01501175 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

flunisolide (3385-03-3,3870-63-1,79284-83-6) → flurandrenolide (1524-88-5)

Guidance literature:

With Wilkinson's catalyst; hydrogen; In ethanol; toluene; for 65h; Ambient temperature;

DOI:10.1016/S0039-128X(97)00107-4

Reference yield:

→ flurandrenolide (1524-88-5)

Guidance literature:

Reference yield:

(4aR,6aS,6bS,9aR,12S)-12-Fluoro-6b-(2-hydroxy-acetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one (1526-01-8,81748-81-4) → 6α-Fluor-16α,17α-isopropylidendioxy-4-pregnen-11β,21-diol-3,20-dion (1524-88-5,3792-16-3,7644-32-8,25541-01-9)

Guidance literature:

In water; N,N-dimethyl-formamide; Curvularia lunata;

DOI:10.1007/BF00776339

upstream raw materials:

(4aR,6aS,6bS,9aR,12S)-12-Fluoro-6b-(2-hydroxy-acetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one

flunisolide

Downstream raw materials:

21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione

Refernces

• 1、 -. "STEROID DERIVATIVES ACTING AS GLUCOCORTICOSTEROID RECEPTOR AGONISTS". Page/Page column 50-51. . Retrieved 2009/07/25.
• 2、 -. "Composition for the topical treatment of poison ivy and other forms of contact dermatitis". . . Retrieved 2008/06/13.