α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate

Base Information

• Chemical Name: α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate
• CAS No.: 246023-21-2
• Molecular Formula: C₁₅H₁₄Cl₂O₃S
• Molecular Weight: 345.246
• Mol file: 246023-21-2.mol

Synonyms:α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate

Chemical Property of α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate

There total 2 articles about α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,2-dichloro-1-phenylethanol (2612-36-4) + p-toluenesulfonyl chloride (98-59-9) → α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate (246023-21-2)

Guidance literature:

With TEA; In dichloromethane; at 25 ℃; for 1.5h;

DOI:10.1021/jo990623z

Reference yield:

benzaldehyde (100-52-7) → α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate (246023-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 2 h / -78 °C

2: 84 percent / TEA / CH₂Cl₂ / 1.5 h / 25 °C

With TEA; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; 1: Addition / 2: Tosylation;

DOI:10.1021/jo990623z

Reference yield: 92.0%

α-(dichloromethyl)benzenemethanol 4-methylbenzenesulfonate (246023-21-2) → phenylacetylene (536-74-3)

Guidance literature:

With methyllithium; In tetrahydrofuran; at -30 - 0 ℃; for 1h;

DOI:10.1021/jo990623z

upstream raw materials:

2,2-dichloro-1-phenylethanol

p-toluenesulfonyl chloride

benzaldehyde

Downstream raw materials:

phenylacetylene