{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester
CAS No.:1604803-39-5
Molecular Formula:C₂₀H₂₂IN₃O₅
Molecular Weight:511.316
Hs Code.:

Synonyms:{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

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Chemical Property of {4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

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Technology Process of {4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

There total 4 articles about {4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1604803-38-4
methyl(3-nitro-4-trimethylsilanylmethylphenyl)carbamic acid tert-butyl ester

: 158669-26-2
4-iodo-2-methoxynicotinaldehyde

: 1604803-39-5
{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

Guidance literature:: methyl(3-nitro-4-trimethylsilanylmethylphenyl)carbamic acid tert-butyl ester; 4-iodo-2-methoxynicotinaldehyde; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 0.5h;

With trifluoroacetic anhydride; In tetrahydrofuran; at 25 ℃; for 0.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 25 - 70 ℃; for 3h;

Reference yield:

: 619-26-1
N-methyl-3-nitroaniline

: 1604803-39-5
{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-aminopyridine / tetrahydrofuran / 3 h / 25 °C

2.1: tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

2.2: 1 h / -70 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

3.2: 0.5 h / 25 °C

3.3: 3 h / 25 - 70 °C

With 4-aminopyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: 528882-15-7
N-methyl-(3-nitrophenyl)carbamic acid tert-butyl ester

: 1604803-39-5
{4-[(E)-2-(4-iodo-2-methoxypyridin-3-yl)vinyl]-3-nitrophenyl}methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

1.2: 1 h / -70 - 0 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

2.2: 0.5 h / 25 °C

2.3: 3 h / 25 - 70 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran;