(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

Base Information

Chemical Name:(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid
CAS No.:206194-04-9
Molecular Formula:C₁₆H₁₀ClF₄NO₅
Molecular Weight:407.706
Hs Code.:

Synonyms:(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

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Chemical Property of (R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

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Technology Process of (R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

There total 4 articles about (R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 206194-05-0
(R)-(+)-5-chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl) phenyl]benzeneacetic acid (R)-α-methylbenzylamine salt

: 206194-04-9
(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

Guidance literature:: With hydrogenchloride; In tert-butylmethylether; water;

Reference yield:

: 26939-01-5
5-chloro-2-methoxyphenylacetic acid,methyl ester

: 206194-04-9
(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: KHDMS / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - -40 °C

1.3: 80 percent / (PhSO₂)2NF / tetrahydrofuran

2.1: (S)-(-)-α-methylbenzylamine

2.2: NaOH

With (S)-1-phenyl-ethylamine; potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1016/S0960-894X(02)00101-4

Reference yield:

: 206194-00-5
5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester

: 206194-04-9
(R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

: 206194-02-7
(S)-(-)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid

Guidance literature:: 5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester; With (S)-1-phenyl-ethylamine;

With sodium hydroxide;
DOI:10.1016/S0960-894X(02)00101-4