(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

Base Information

Chemical Name:(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate
CAS No.:948591-08-0
Molecular Formula:C₁₇H₂₃ClN₂O₅
Molecular Weight:370.833
Hs Code.:

Synonyms:(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

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Chemical Property of (+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

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Technology Process of (+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

There total 4 articles about (+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 948591-05-7
(-)-methyl [(2S,3R)-3-amino-2-(benzyloxycarbonylamino)-4-methyl]pentanoate

: 79-04-9
chloroacetyl chloride

: 948591-08-0
(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tet.2007.05.062

Reference yield:

: (+)-methyl [(2S,4R,5S,S_S)-1-benzyloxycarbonyl-2-phenyl-4-(iso-propyl)-3-(p-tolylsulfinyl)-1,3-imidazolidin-5-yl]carboxylate

: 948591-08-0
(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 107 mg / aq. H₃PO₄ / methanol / 18 h / 0 - 20 °C

2: 85 percent / NaHCO₃ / ethyl acetate; H₂O / 4 h / 0 - 20 °C

With phosphoric acid; sodium hydrogencarbonate; In methanol; water; ethyl acetate;
DOI:10.1016/j.tet.2007.05.062

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 948591-08-0
(+)-methyl [(2S,3R)-2-(benzyloxycarbonylamino)-3-(chloroacetylamino)-4-methyl]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / CH₂Cl₂; H₂O / 3 h / 0 - 20 °C

2: 107 mg / aq. H₃PO₄ / methanol / 18 h / 0 - 20 °C

3: 85 percent / NaHCO₃ / ethyl acetate; H₂O / 4 h / 0 - 20 °C

With sodium hydroxide; phosphoric acid; sodium hydrogencarbonate; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tet.2007.05.062