3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

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Chemical Name:3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid
CAS No.:1232407-01-0
Molecular Formula:C₂₉H₄₁NO₄
Molecular Weight:467.649
Hs Code.:

Synonyms:3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

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Chemical Property of 3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

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Technology Process of 3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

There total 7 articles about 3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1232407-05-4
methyl 3-{2-[(1R)-1-({(5R)-3-[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]-2-oxo-1,3-oxazolidin-5-yl}methoxy)ethyl]phenyl}-2,2-dimethylpropanoate

: 1232407-01-0
3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

Guidance literature:: methyl 3-{2-[(1R)-1-({(5R)-3-[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]-2-oxo-1,3-oxazolidin-5-yl}methoxy)ethyl]phenyl}-2,2-dimethylpropanoate; With water; potassium hydroxide; In methanol; at 100 ℃; for 26h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 351490-85-2
1,1-dimethyl-2-(indan-2-yl)ethylamine

: 1232407-01-0
3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium perchlorate / toluene / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 760.05 Torr

3.1: dmap / tetrahydrofuran / 26 h / 50 °C

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

4.2: 1.25 h / -78 °C

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

5.2: 22 h / 20 °C

6.1: potassium hydroxide; water / methanol / 26 h / 100 °C

With dmap; n-butyllithium; water; hydrogen; lithium perchlorate; diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; toluene;

Reference yield:

: 1232828-91-9
methyl (2E)-3-(2-{(1R)-1-[(2R)-oxiran-2-yl methoxy]ethyl}phenyl)prop-2-enoate

: 1232407-01-0
3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium perchlorate / toluene / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 760.05 Torr

3.1: dmap / tetrahydrofuran / 26 h / 50 °C

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

4.2: 1.25 h / -78 °C

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

5.2: 22 h / 20 °C

6.1: potassium hydroxide; water / methanol / 26 h / 100 °C

With dmap; n-butyllithium; water; hydrogen; lithium perchlorate; diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; toluene;