1H-Indene-2-ethanamine, 2,3-dihydro-.alpha.,.alpha.-dimethyl-

Base Information

• Chemical Name: 1H-Indene-2-ethanamine, 2,3-dihydro-.alpha.,.alpha.-dimethyl-
• CAS No.: 351490-85-2
• Molecular Formula: C13H19N
• Molecular Weight: 189.301
• Mol file: 351490-85-2.mol

Synonyms:1H-INDENE-2-ETHANAMINE, 2,3-DIHYDRO-.ALPHA.,.ALPHA.-DIMETHYL-;1-(2,3-DIHYDRO-1H-INDEN-2-YL)-2-METHYLPROPAN-2-AMINE;

Chemical Property of 1H-Indene-2-ethanamine, 2,3-dihydro-.alpha.,.alpha.-dimethyl-

Chemical Property:

• Boiling Point: 288.2±9.0 °C(Predicted)
• PKA: 10.53±0.25(Predicted)
• PSA: 26.02000
• Density: 0.981±0.06 g/cm3(Predicted)
• LogP: 3.22910

Purity/Quality:

99% ^*data from raw suppliers

1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-amine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene-2-ethanamine, 2,3-dihydro-.alpha.,.alpha.-dimethyl-

There total 4 articles about 1H-Indene-2-ethanamine, 2,3-dihydro-.alpha.,.alpha.-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

N-(1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)acetamide (351490-87-4) → 1,1-dimethyl-2-(indan-2-yl)ethylamine (351490-85-2)

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 190 ℃; for 24h;

Reference yield:

2-(indan-2-yl)acetic acid (37868-26-1) → 1,1-dimethyl-2-(indan-2-yl)ethylamine (351490-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 16 h / 0 - 20 °C

2: diethyl ether / 2 h / 20 °C / Cooling with ice

3: sulfuric acid; acetic acid / 16 h / 20 °C / Cooling with ice

4: potassium hydroxide / ethylene glycol / 24 h / 190 °C

With thionyl chloride; sulfuric acid; acetic acid; potassium hydroxide; In diethyl ether; ethylene glycol;

Reference yield:

1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-ol (351490-86-3) → 1,1-dimethyl-2-(indan-2-yl)ethylamine (351490-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; acetic acid / 16 h / 20 °C / Cooling with ice

2: potassium hydroxide / ethylene glycol / 24 h / 190 °C

With sulfuric acid; acetic acid; potassium hydroxide; In ethylene glycol;

upstream raw materials:

N-(1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)acetamide

2-(indan-2-yl)acetic acid

1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-ol

indan-2-yl-acetic acid methyl ester

Downstream raw materials:

SB-423557

3-{2-[(1R)-1-{[(2R)-3-{[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropyl]oxy}ethyl]phenyl}propanoic acid

methyl 3-{2-[(1R)-1-({(5R)-3-[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]-2-oxo-1,3-oxazolidin-5-yl}methoxy)ethyl]phenyl}-2,2-dimethylpropanoate

Methyl 3-(2-[(1R)-1-({(5R)-3-[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]-2-oxo-1,3-oxazolidin-5-yl}methoxy)ethyl]phenyl}-2-methylpropanoate