1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Base Information

Chemical Name:1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one
CAS No.:107079-81-2
Molecular Formula:C₂₉H₃₂N₂O₂
Molecular Weight:440.585
Hs Code.:

Synonyms:1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

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Chemical Property of 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

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Technology Process of 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

There total 7 articles about 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107079-80-1
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

: 107079-81-2
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -95 ℃; for 4h;
DOI:10.1021/ja00240a033

Reference yield:

: 100-39-0
benzyl bromide

: 107079-81-2
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) potassium hydride / 1.) THF, RT, 17.5 h; 2.) THF, RT, 3 h

2: 92 percent / sodium sulfate / benzene / Ambient temperature

3: triethylamine / CH₂Cl₂ / -78 deg C to room temperature

4: H₂ / 5 percent Pd-C / methanol / 6 h / 0 - 5 °C

5: sodium sulfate / benzene / Ambient temperature

6: 90 percent / lithium diisopropylamide / tetrahydrofuran / 4 h / -95 °C

With hydrogen; potassium hydride; sodium sulfate; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ja00240a033

Reference yield:

: 82166-23-2
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3R,4S)-3-azido-4-phenylazetidin-2-one

: 107079-81-2
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(3S,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5 percent Pd-C / methanol / 6 h / 0 - 5 °C

2: sodium sulfate / benzene / Ambient temperature

3: 90 percent / lithium diisopropylamide / tetrahydrofuran / 4 h / -95 °C

With hydrogen; sodium sulfate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/ja00240a033