Pyridazino(4,5-b)quinoxalin-1(2H)-one

Base Information

• Chemical Name: Pyridazino(4,5-b)quinoxalin-1(2H)-one
• CAS No.: 61857-87-2
• Molecular Formula: C₁₀H₆N₄O
• Molecular Weight: 198.184
• DSSTox Substance ID: DTXSID50210834
• Wikidata: Q83085631
• Mol file: 61857-87-2.mol

Synonyms:Pyridazino(4,5-b)quinoxalin-1(2H)-one;61857-87-2;BRN 1111326;3H-pyridazino[4,5-b]quinoxalin-4-one;DTXSID50210834;C10-H6-N4-O;LS-130071

Chemical Property of Pyridazino(4,5-b)quinoxalin-1(2H)-one

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 71.79000
• Density: 1.59g/cm³
• LogP: 1.27860
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 198.05416083
• Heavy Atom Count: 15
• Complexity: 304

Purity/Quality:

PYRIDAZINO-(4,5-B)QUINOXALIN-1-(2H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C3C=NNC(=O)C3=N2

Technology Process of Pyridazino(4,5-b)quinoxalin-1(2H)-one

There total 7 articles about Pyridazino(4,5-b)quinoxalin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline 5,10-dioxide (95663-69-7) → 1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline (61857-87-2)

Guidance literature:

With sodium dithionite; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570210505

Reference yield: 70.0%

2-Ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide (71320-68-8) → 1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline (61857-87-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 9h; Heating;

DOI:10.1002/jhet.5570210505

Reference yield: 60.0%

3-dichloromethyl-2-quinoxalinecarboxylic acid ethyl ester 1,4-dioxide (61857-88-3) → 1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline (61857-87-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Ambient temperature;

DOI:10.1002/jhet.5570210505

upstream raw materials:

1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline 5,10-dioxide

2-Ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide

3-dichloromethyl-2-quinoxalinecarboxylic acid ethyl ester 1,4-dioxide

benzofurazan oxide

Downstream raw materials:

1-Hydrazinopyridazino<4,5-b>quinoxaline

1-<2-(phenylmethylene)hydrazino>pyridazino<4,5-b>quinoxaline

N-[1-Phenyl-eth-(E)-ylidene]-N'-(2,3,9,10-tetraaza-anthracen-1-yl)-hydrazine

N-(2,3,9,10-Tetraaza-anthracen-1-yl)-N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazine

Refernces

• 1、 Monge Vega,Gil,Fernandez-Alvarez. "Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds". . p. 1271 - 1276. Retrieved 2007/10/02.