Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate

Base Information

Chemical Name:Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate
CAS No.:174606-15-6
Molecular Formula:C₂₀H₂₈ClNO₄
Molecular Weight:381.9
Hs Code.:
DSSTox Substance ID:DTXSID101128424
Mol file:174606-15-6.mol

Synonyms:SCHEMBL8878002;Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate;WNGGTHAIXPWVPG-UHFFFAOYSA-N;DTXSID101128424;174606-15-6;Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-carboxylate;1-(1,1-Dimethylethyl) 3-ethyl 3-[(4-chlorophenyl)methyl]-1,3-piperidinedicarboxylate

Suppliers and Price of Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:381.1706861
Heavy Atom Count:26
Complexity:497

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1(CCCN(C1)C(=O)OC(C)(C)C)CC2=CC=C(C=C2)Cl

Technology Process of Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate

There total 2 articles about Ethyl-3-(4-chlorobenzyl)-N-Boc-piperidin-3-caroxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 148672-74-6,130250-54-3
ethyl N-(t-butyloxycarbonyl)nipecotate

: 622-95-7
4-chlorobenzyl bromide

: 174606-15-6
1-(tert-butyl) 3-ethyl 3-(4-chlorobenzyl)piperidine-1,3-dicarboxylate

Guidance literature:: ethyl N-(t-butyloxycarbonyl)nipecotate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -30 ℃; for 0.666667h;

4-chlorobenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.ejmech.2018.09.073

Reference yield:

: 148672-74-6,130250-54-3
ethyl N-(t-butyloxycarbonyl)nipecotate

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 4039-32-1
lithium hexamethyldisilazane

: 174606-15-6
1-(tert-butyl) 3-ethyl 3-(4-chlorobenzyl)piperidine-1,3-dicarboxylate

Guidance literature:: In tetrahydrofuran;

Reference yield: 56.0%

: 372-47-4
3-Fluoropyridine

: 174606-15-6
1-(tert-butyl) 3-ethyl 3-(4-chlorobenzyl)piperidine-1,3-dicarboxylate

: tert-butyl 3-(4-chlorobenzyl)-3-((pyridin-3-yloxy)methyl)piperidine-1-carboxylate

Guidance literature:: 1-(tert-butyl) 3-ethyl 3-(4-chlorobenzyl)piperidine-1,3-dicarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

3-Fluoropyridine; In N,N-dimethyl-formamide; at 0 ℃; for 10h; Alkaline conditions; Heating;
DOI:10.1016/j.ejmech.2018.09.073