(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

Base Information

Chemical Name:(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate
CAS No.:1321964-35-5
Molecular Formula:C₂₅H₂₈F₃N₃O₃
Molecular Weight:475.511
Hs Code.:

Synonyms:(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

Chemical Property:

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Technology Process of (1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

There total 1 articles about (1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4238-71-5
1-benzylimidazole

: 19009-39-3
N,N-diisopropylcarbamoyl chloride

: 659-28-9
p-trifluoromethoxybenzaldehyde

: 1321964-35-5
(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 19h; Inert atmosphere; Reflux;
DOI:10.1021/jm1010644

Reference yield: 82.0%

: 1321964-35-5
(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

: 1321963-91-0
(1-benzyl-1H-imidazol-2-yl)(4-trifluoromethoxyphenyl)-methanol

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; water; for 15h; Reflux;
DOI:10.1021/jm1010644

Reference yield:

: 1321964-35-5
(1-benzyl-1H-imidazol-2-yl)(4-(trifluoromethoxy)phenyl)-methyl diisopropylcarbamate

: 1345722-24-8
C₁₂H₁₁F₃N₂O₄S

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / tetrahydrofuran; water / 15 h / Reflux

2: 5%-palladium/activated carbon; hydrogen; acetic acid / methanol / 2.5 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm1010644