3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

Base Information

Chemical Name:3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one
CAS No.:934190-95-1
Molecular Formula:C₂₁H₂₂BrNO₄
Molecular Weight:432.314
Hs Code.:

Synonyms:3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

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Chemical Property of 3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

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Technology Process of 3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

There total 1 articles about 3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-acryloyl]-4-phenyl-oxazolidin-2-one

: 75-16-1
methylmagnesium bromide

: 934190-95-1
3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 - -20 ℃;
DOI:10.3987/com-06-s(w)19

Reference yield:

: 934190-95-1
3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

: 6-[2-(2-methoxy-4-methyl-phenyl)-propionyl]-5,9-dimethyl-7-methylene-2-oxa-bicyclo[3.3.1]nonan-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: LiBH₄; MeOH / tetrahydrofuran / 0 - 20 °C

1.2: o-SeCN-C₆H₄-NO₂; PBu₃ / tetrahydrofuran / 0 °C

1.3: aq. H₂O₂ / tetrahydrofuran

2.1: 78 percent / O₃; Sudan Red; PPh₃ / CH₂Cl₂ / -78 °C

3.1: 96 percent / DDQ; buffer / CH₂Cl₂ / pH 7

4.1: Dess-Martin reagent

4.2: 98 percent / LiBr; Et₃N

5.1: Bu₄NBr; LiHMDS / 0.5 h / -78 °C

5.2: 40 percent / Bu₃SnCl / -78 - 20 °C

6.1: 76 percent / Bu₃SnH; AIBN / benzene / 85 °C

7.1: Et₃N

With methanol; lithium borohydride; 2,2'-azobis(isobutyronitrile); sudan red; tetrabutylammomium bromide; tri-n-butyl-tin hydride; Dess-Martin periodane; ozone; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; benzene; 5.1: Dess-Martin oxidation / 5.2: Horner-Wadsworth-Emmons cyclization;
DOI:10.3987/com-06-s(w)19

Reference yield:

: 934190-95-1
3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one

: 934190-96-2
1-bromo-3-methoxy-5-methyl-2-(1-methyl-allyl)-benzene

Guidance literature:: 3-[3-(2-bromo-6-methoxy-4-methyl-phenyl)-butyryl]-4-phenyl-oxazolidin-2-one; With methanol; lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

With ortho-nitrophenyl selenocyanate; tributylphosphine; In tetrahydrofuran; at 0 ℃;

With dihydrogen peroxide; In tetrahydrofuran;
DOI:10.3987/com-06-s(w)19