5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Base Information

Chemical Name:5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole
CAS No.:908338-99-8
Molecular Formula:C₃₈H₄₇NO₈Si
Molecular Weight:673.879
Hs Code.:

Synonyms:5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

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Chemical Property of 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Chemical Property:

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Technology Process of 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

There total 12 articles about 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908338-93-2
triethyl-[1,4,5,7,8-pentamethoxy-3-(2-nitro-ethyl)-naphthalen-2-yloxy]-silane

: 67191-36-0
1-(benzyloxy)-2-ethenylbenzene

: 908338-99-8
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: With phenyl isocyanate; triethylamine; In benzene; at 20 ℃; for 48h;
DOI:10.1021/ol061112j

Reference yield:

: 908339-09-3
(3-hydroxymethyl-1,4,5,7,8-pentamethoxy-naphthalen-2-yl)-methanol

: 908338-99-8
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / imidazole / dimethylformamide / 20 °C

2: 88 percent / DDQ / CH₂Cl₂; H₂O / 1 h / 20 °C

3: 93 percent / NH₄OAc / 0.75 h / Heating

4: 100 percent / sodium borohydride; silica gel / CHCl₃; propan-2-ol / 1.5 h / 20 °C

5: 95 percent / aq. HCl / methanol / 0.5 h / 20 °C

6: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.75 h / 20 °C

7: B(OH)3; H₂O₂; H₂SO₄ / tetrahydrofuran; H₂O / 9 h / 20 °C

8: 196 mg / imidazole / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

9: phenyl isocyanate; triethylamine / benzene / 48 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; sulfuric acid; ammonium acetate; dihydrogen peroxide; boric acid; silica gel; Dess-Martin periodane; phenyl isocyanate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; benzene; 3: Henry condensation / 7: Dakin oxidation;
DOI:10.1021/ol061112j

Reference yield:

: 908339-13-9
1,4,5,7,8-pentamethoxy-3-(2-nitro-ethyl)-naphthalene-2-carbaldehyde

: 908338-99-8
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: B(OH)3; H₂O₂; H₂SO₄ / tetrahydrofuran; H₂O / 9 h / 20 °C

2: 196 mg / imidazole / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

3: phenyl isocyanate; triethylamine / benzene / 48 h / 20 °C

With 1H-imidazole; sulfuric acid; dihydrogen peroxide; boric acid; phenyl isocyanate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; benzene; 1: Dakin oxidation;
DOI:10.1021/ol061112j