10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Base Information

Chemical Name:10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one
CAS No.:1399175-28-0
Molecular Formula:C₂₀H₂₄F₃NO₄
Molecular Weight:399.41
Hs Code.:

Synonyms:10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

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Chemical Property of 10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

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Technology Process of 10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

There total 5 articles about 10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292278-80-8
10-[4-((R)-2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

: 74-88-4
methyl iodide

: 1399175-28-0
10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Guidance literature:: 10-[4-((R)-2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.916667h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.91667h;

Reference yield:

: 1292278-69-3
8-cyanomethyl-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester

: 1399175-28-0
10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 18 h / 20 °C

2.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 6.5 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.92 h / 0 °C / Inert atmosphere

3.2: 1.92 h / 0 - 20 °C

With potassium phosphate; copper(l) iodide; hydrogen; sodium hydride; acetic acid; N,N`-dimethylethylenediamine; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1399175-28-0
10-[4-((R)-2,2,2-Trifluoro-1-methoxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 1.17 h / -5 - 0 °C

1.2: 16.17 h / -5 - 20 °C

2.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 18 h / 20 °C

3.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 6.5 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.92 h / 0 °C / Inert atmosphere

4.2: 1.92 h / 0 - 20 °C

With potassium phosphate; copper(l) iodide; hydrogen; sodium hydride; acetic acid; N,N`-dimethylethylenediamine; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; mineral oil;