2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

Base Information

Chemical Name:2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one
CAS No.:1447249-91-3
Molecular Formula:C₂₃H₁₇Cl₂N₃O
Molecular Weight:422.313
Hs Code.:

Synonyms:2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

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Chemical Property of 2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

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Technology Process of 2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

There total 3 articles about 2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1395347-62-2
6-bromo-2-cyclopropyl-3-((pyridin-3-yl)methyl)quinazolin-4(3H)-one

: 73852-17-2
2,6-dichlorophenylboronic acid

: 1447249-91-3
2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

Guidance literature:: With potassium phosphate; [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); In 1,4-dioxane; at 80 ℃; for 8h; Inert atmosphere; Sealed tube;
DOI:10.1039/c3ob40636a

Reference yield:

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 1447249-91-3
2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / 2.5 h / 0 - 20 °C

2: acetic acid / 2 h / Reflux

3: potassium phosphate; [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II) / 1,4-dioxane / 8 h / 80 °C / Inert atmosphere; Sealed tube

With 2,6-dimethylpyridine; potassium phosphate; [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); acetic acid; In 1,4-dioxane; 3: |Suzuki-Miyaura Coupling;
DOI:10.1039/c3ob40636a

Reference yield:

: 6-bromo-2-cyclopropyl-4H-benzo[d][1,3]oxazin-4-one

: 1447249-91-3
2-cyclopropyl-6-(2,6-dichlorophenyl)-3-(pyridin-3-ylmethyl)-quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h / Reflux

2: potassium phosphate; [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II) / 1,4-dioxane / 8 h / 80 °C / Inert atmosphere; Sealed tube

With potassium phosphate; [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); acetic acid; In 1,4-dioxane; 2: |Suzuki-Miyaura Coupling;
DOI:10.1039/c3ob40636a