2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Base Information

Chemical Name:2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide
CAS No.:1354652-90-6
Molecular Formula:C₂₃H₂₂F₃N₅O
Molecular Weight:441.456
Hs Code.:

Synonyms:2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

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Chemical Property of 2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

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Technology Process of 2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

There total 4 articles about 2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1354652-89-3
2-nitro-5-(piperidin-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

: 1354652-90-6
2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1354652-90-6
2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water; methanol / 135 °C / Inert atmosphere; Sealed tube

2: pyridine / dichloromethane / 2 h / 25 °C

3: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

With pyridine; hydrogen; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 59489-74-6
5-(3-(trifluoromethyl)phenyl)pyrazin-2-amine

: 1354652-90-6
2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 2 h / 25 °C

2: potassium carbonate / N,N-dimethyl-formamide / 100 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;