5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Base Information

• Chemical Name: 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide
• CAS No.: 1354652-88-2
• Molecular Formula: C₁₈H₁₀ClF₃N₄O₃
• Molecular Weight: 422.751
• Mol file: 1354652-88-2.mol

Synonyms:5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Chemical Property of 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

There total 2 articles about 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-(3-(trifluoromethyl)phenyl)pyrazin-2-amine (59489-74-6) + 5-chloro-2-nitrobenzoyl chloride (41994-44-9) → 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-88-2)

Guidance literature:

With pyridine; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

(meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water; methanol / 135 °C / Inert atmosphere; Sealed tube

2: pyridine / dichloromethane / 2 h / 25 °C

With pyridine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield: 76.0%

piperidine (110-89-4) + 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-88-2) → 2-nitro-5-(piperidin-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide (1354652-89-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

upstream raw materials:

(meta-(trifluoromethyl)phenyl)boronic acid

5-(3-(trifluoromethyl)phenyl)pyrazin-2-amine

5-chloro-2-nitrobenzoyl chloride

Downstream raw materials:

2-nitro-5-(piperidin-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

2-amino-5-(piperidine-1yl)-N-(5-(3-(trifluoromethyl)phenyl)pyrazine-2yl)benzamide

N₁-(2-(2-hydroxyethoxy)ethyl)-N₃-(4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)isophthalamide

tert-butyl 3-(3-((4-(piperidin-1-yl)-2-((5-(3-(trifluoromethyl)phenyl)pyrazin-2-yl)carbamoyl)phenyl)carbamoyl)benzylthio)propanoate