2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

Base Information

Chemical Name:2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid
CAS No.:1123515-34-3
Molecular Formula:C₂₀H₁₇F₂N₃O₄
Molecular Weight:401.369
Hs Code.:

Synonyms:2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

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Chemical Property of 2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

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Technology Process of 2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

There total 2 articles about 2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887757-48-4
2-(4-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1123515-31-0
2-(4-(5-bromopyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

: 1123515-34-3
2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

Guidance literature:: 2-(4-(difluoromethoxy)phenyl)-4.4.5.5-tetramethyl-1,3,2-dioxaborolane; 2-(4-(5-bromopyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 0.166667h;

With hydrogenchloride; In water; pH=5; Product distribution / selectivity;

Reference yield:

: 1123515-49-0
ethyl 2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoate

: 1123515-34-3
2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoic acid

Guidance literature:: ethyl 2-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)-3-hydroxypropanoate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=5; Product distribution / selectivity;