406-34-8

Basic information

• Product Name: Ethanamine, 2-fluoro-
• Synonyms: 2-Fluoroethylamine;Ethanamine, 2-fluoro-;(2-fluoroethyl)amine(SALTDATA: HCl);2-fluoroethanaMine;1-Amino-2-fluoroethane;2-Fluoro-1-ethanamine
• CAS NO: 406-34-8
• Molecular Formula: C₂H₆FN
• Molecular Weight: 63.0741432
• Mol File: 406-34-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 103-104 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 39-42 °C
• Appearance: /
• Density: 0.892±0.06 g/cm3(Predicted)
• PKA: 8.71±0.10(Predicted)
• CAS DataBase Reference: Ethanamine, 2-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanamine, 2-fluoro-(406-34-8)
• EPA Substance Registry System: Ethanamine, 2-fluoro-(406-34-8)

Safety Data

• Hazardous Substances Data: 406-34-8(Hazardous Substances Data)

Usage

General Description

Ethanamine, 2-fluoro-, also known as 2-fluoroethylamine, is a chemical compound with the formula C2H5F. This organic compound is classified as an amine, due to the presence of an amino group (-NH2) attached to an ethyl chain. It is a colorless liquid with a distinct ammonia-like odor, and is commonly used in the synthesis of pharmaceuticals and other organic compounds. 2-fluoroethylamine is also used as an intermediate in the production of pesticides, dyes, and other chemicals. Ethanamine, 2-fluoro- is highly reactive and should be handled with caution due to its potential to cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 93630-43-4 (1R,2S,3R,4S)-3-(2-Fluoro-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 

Downstream Products

• 331-07-7 N-(2-fluoro-ethyl)-N'-phenyl-urea 
• 13907-94-3 1-Cyclohexyl-3-(2-fluoro-ethyl)-urea 
• 13907-99-8 1,1'-p-Phenylenebis<3-(2-fluoroethyl)urea> 
• 13907-92-1 1,3-bis-(2-fluoroethyl) urea 
• 78604-21-4 1-(p-acetylphenyl)-3-(2-fluoroethyl)triazene 
• 417722-66-8 (2-fluoroethyl)carbamate phenyl ester 
• 1174765-25-3 1-{4-[4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl}-3-(2-fluoroethyl)urea 
• 1174765-73-1 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea 
• 1062172-18-2 C₂₇H₃₅FN₈O₄ 
• 1062172-27-3 C₂₇H₃₅FN₈O₄ 
• 1243675-43-5 C₃₅H₄₅ClF₃N₃O₂ 
• 78604-22-5 1-(p-ethoxycarbonylphenyl)-3-(2-fluoroethyl)triazene 
• 78604-33-8 1-(o-nitrophenyl)-3-(2-fluoroethyl)triazene 
• 13907-90-9 N-<2-Fluor-ethyl>-harnstoff 

Relevant articles and documents

Structural effects on reactivity in intramolecular catalysis. The hydrolysis of N-alkylated monoamides derived from norbornene-2,3-dicarboxylic acid

Monoamides of 2,3-endo-cis-5-norbornene dicarboxylic acid (compounds 1-5) were prepared by addition of primary alkyl amines (n-propyl-, 2-methoxyethyl-, 2-fluoroethyl-, 2,2-difluoroethyl-, 2,2,2-trifluoroethyl-) to 2,3-endo-cis-5-norbornene dicarboxylic anhydride.The rates of hydrolysis of each compound in solutions whose acid concentration ranged from 0.01 M to 9 M were determined.Rates increase with acidity above 0.1 M until a maximum rate is achieved in strong acid.The results are consistent with a mechanism involving intramolecular catalysis of the hydrolysis of the amide by the adjacent carboxylic acid.The dependence of rate on acidity can be interpreted in terms of a multistep mechanism involving formation of an intramolecular tetrahedral adduct, tautomerization of the adduct, and expulsion of the amine to give the anhydride.The identity of the rate-determining step is a function of the basicity of the substrate and the acidity of the medium.Analysis of the data in terms of the proposed mechanism suggests that the effective molarity of the groups involved in tautomerization of the tetrahedral internal addition intermediate is higher than in other rigid systems which lack the norbornene structure.It is proposed that ring strain and rotational entropy control cyclization and elimination steps.Interactions of the solvent with the entire substrate control reorganization of the intermediate.Conjugation of the interacting functional groups does not appear to have a significant effect upon their reactivity.