7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine
CAS No.:1353571-89-7
Molecular Formula:C₂₂H₂₀IN₃O₄S₂
Molecular Weight:581.455
Hs Code.:

Synonyms:7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

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Chemical Property of 7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

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Technology Process of 7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

There total 9 articles about 7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.16%

: 1353571-88-6
7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazine

: 98-59-9
p-toluenesulfonyl chloride

: 1353571-89-7
7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1353571-89-7
7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 1 h / 60 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.17 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

5.1: water; sodium carbonate / methanol / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

6.2: 0.5 h

7.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

8.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

9.2: 16 h / 20 °C

With pyridine; dmap; potassium phosphate; N-Bromosuccinimide; potassium tert-butylate; water; Iodine monochloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1353571-89-7
7-iodo-2-(4-(isopropylsulfonyl)phenyl)-5-(p-tolylsulfonyl)pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: water; sodium carbonate / methanol / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5.2: 0.5 h

6.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

7.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

8.2: 16 h / 20 °C

With pyridine; dmap; N-Bromosuccinimide; potassium tert-butylate; water; Iodine monochloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;