850567-98-5Relevant academic research and scientific papers
Preparation method of 4-isopropylsulfonylphenylboronic acid
-
, (2021/04/26)
The invention discloses a preparation method of 4-isopropylsulfonylphenylboronic acid, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps of: taking 4-bromothiophenol and halogenated isopropane as the raw materials, and acquiring 1-bromo-4-isopropyl thiobenzene under the action of potassium carbonate; performing oxidizing with hydrogen peroxide in the presence of a catalyst to obtain 1-bromo-4-isopropylsulfonylbenzene, and finally, carrying out Grignard exchange/borate reaction with a Grignard reagent to obtain 4-isopropylsulfonylphenylboronic acid. The method has the advantages of high yield, simple process, cheap and easily available raw materials, green chemistry, and 6 times of application of the catalyst, and has an industrial amplification prospect.
