Nomega-Nitro-L-arginine

Base Information

• Chemical Name: Nomega-Nitro-L-arginine
• CAS No.: 2149-70-4
• Molecular Formula: C6H13N5O4
• Molecular Weight: 219.2
• Hs Code.: 29299090
• NSC Number: 53662
• DSSTox Substance ID: DTXSID10859703
• Mol file: 2149-70-4.mol

Synonyms:N omega Nitro L Arginine;N omega-Nitro-L-Arginine;N(G)-Nitroarginine;N(omega)-Nitroarginine;NG Nitro L Arginine;NG Nitroarginine;NG-Nitro-L-Arginine;NG-Nitroarginine;Nitroarginine;NO2Arg;NOARG;omega Nitroarginine;omega-Nitro-L-Arginine, N;omega-Nitroarginine

Chemical Property of Nomega-Nitro-L-arginine

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 257 °C (dec.)(lit.)
• Refractive Index: 1.638
• Boiling Point: 462.4 °C at 760 mmHg
• PKA: 2.49±0.24(Predicted)
• Flash Point: 233.5 °C
• PSA: 157.05000
• Density: 1.65 g/cm³
• LogP: 0.58920
• Storage Temp.: Store at RT.
• XLogP3: -3.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 219.09675391
• Heavy Atom Count: 15
• Complexity: 261

Purity/Quality:

≥98%, ^*data from raw suppliers

L-NNA ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(C(=O)O)N)CN=C(N)N[N+](=O)[O-]
• Uses: Nω-Nitro-L-arginine is an inhibitor for nitric oxide synthase and is used in the study of bacterium to determine effective treatments. Used in the study of MRSA (Methicillin-Resistant Staphylococcus Aureus).

Technology Process of Nomega-Nitro-L-arginine

There total 11 articles about Nomega-Nitro-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-arginine (74-79-3,25212-18-4) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With nitric acid;

Reference yield:

L-arginine hydrochloride (1119-34-2) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With sulfuric acid; sulfur trioxide; nitric acid; Nitrogen dioxide;

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → N-nitro-L-arginine (2149-70-4,13855-78-2,38733-00-5)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1246/bcsj.38.1148

upstream raw materials:

D-arginine

L-arginine

Boc-Arg(NO₂)-OH

L-arginine hydrochloride

Downstream raw materials:

nitro-L-arginine methyl ester hydrochloride

N^ω-nitro-L-arginine ethyl ester; hydrochloride

Z-glycyl-N^G-nitro-L-arginine

Boc-Arg(NO₂)-OH

Refernces

• 1、 Mou, Jiajia,Luan, Yepeng,Chen, Danghui,Wang, Qiang. "Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation". . p. 3015 - 3025. Retrieved 2017/10/06.
• 2、 Mou, Jiajia,Fang, Hao,Jing, Fanbo,Wang, Qiang,Liu, Yingzi,Zhu, Huawei,Shang, Luqing,Wang, Xuejian,Xu, Wenfang. "Design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase N/CD13 inhibitors". scheme or table. p. 4666 - 4673. Retrieved 2009/12/01.