tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Base Information

Chemical Name:tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate
CAS No.:936755-55-4
Molecular Formula:C₃₁H₃₀F₂N₆O₆
Molecular Weight:620.613
Hs Code.:

Synonyms:tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

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Chemical Property of tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

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Technology Process of tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

There total 11 articles about tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913739-29-4
tert-butyl (3-amino-1-phenyl-1H-pyrazol-4-yl)carbamate

: 936755-54-3
4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

: 936755-55-4
tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Guidance literature:: With (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 60 ℃; for 16h;

Reference yield:

: 98-80-6
phenylboronic acid

: 936755-55-4
tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / copper diacetate / dichloromethane / 48 h / 20 °C

2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

3.2: 16 h / 20 °C

4.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 16 h / 60 °C

With pyridine; potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; copper diacetate; In tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;

Reference yield:

: 701917-02-4
4-nitro-1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester

: 936755-55-4
tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

2.2: 16 h / 20 °C

3.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 16 h / 60 °C

With potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diphenylphosphoryl azide; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;