tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Base Information

• Chemical Name: tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate
• CAS No.: 936755-56-5
• Molecular Formula: C₃₁H₂₈F₂N₆O₅
• Molecular Weight: 602.597
• Mol file: 936755-56-5.mol

Synonyms:tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Chemical Property of tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

There total 13 articles about tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate (936755-55-4) → tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate (936755-56-5)

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; at 100 ℃; for 0.166667h; Microwave;

Reference yield:

phenylboronic acid (98-80-6) → tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate (936755-56-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / copper diacetate / dichloromethane / 48 h / 20 °C

2.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

3.2: 16 h / 20 °C

4.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 16 h / 60 °C

6.1: Burgess reagent / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

With pyridine; potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Burgess reagent; diphenylphosphoryl azide; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; copper diacetate; In tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;

Reference yield:

4-nitro-1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester (701917-02-4) → tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate (936755-56-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine; diphenylphosphoryl azide / 1,3-dioxane; tert-butyl alcohol / 16 h / Heating / reflux

2.2: 16 h / 20 °C

3.1: triethylamine; hydrogen / platinum(IV) oxide / methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 16 h / 60 °C

5.1: Burgess reagent / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

With potassium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Burgess reagent; diphenylphosphoryl azide; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; 1,3-dioxane; methanol; dichloromethane; tert-butyl alcohol;

upstream raw materials:

tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate

phenylboronic acid

ethyl-4-cyanobenzoylformate

4-nitro-1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester