[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Base Information

Chemical Name:[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester
CAS No.:304655-64-9
Molecular Formula:C₁₅H₂₀N₄O₄
Molecular Weight:320.348
Hs Code.:

Synonyms:[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Suppliers and Price of [(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

There total 9 articles about [(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 228267-29-6
(3R)-N-allyloxycarbonyl-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylamine

: 304655-64-9
[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Guidance literature:: (3R)-N-allyloxycarbonyl-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylamine; With TEA; methanesulfonyl chloride; In dichloromethane; at 0 ℃;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;

With toluene-4-sulfonic acid; In methanol; at 20 ℃;
DOI:10.1016/S0968-0896(00)00125-5

Reference yield:

: [1-(4-Azidomethyl-phenyl)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-carbamic acid allyl ester

: 304655-64-9
[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃;
DOI:10.1016/S0960-894X(99)00657-5

Reference yield:

: 87736-74-1
4-(tert-butyldimethylsiloxymethyl)bromobenzene

: 304655-64-9
[(R)-1-(4-Azidomethyl-phenyl)-3,4-dihydroxy-butyl]-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88.8 percent / n-BuLi / tetrahydrofuran; hexane / -70 °C

2.1: PPh₃; DEAD; DPPA / tetrahydrofuran / 0 °C

3.1: PPh₃ / tetrahydrofuran; H₂O / 5 h / 50 °C

3.2: Et₃N / tetrahydrofuran / 0 °C

4.1: MsCl; TEA / CH₂Cl₂ / 0 °C

4.2: NaN₃ / dimethylformamide / 20 °C

4.3: p-TsOH / methanol / 20 °C

With n-butyllithium; TEA; diphenyl-phosphinic acid; methanesulfonyl chloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; water; 1.1: Condensation / 2.1: Substitution / 3.1: Reduction / 3.2: Acylation / 4.1: Substitution / 4.2: Substitution / 4.3: Hydrolysis;
DOI:10.1016/S0968-0896(00)00125-5