(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

Base Information

Chemical Name:(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene
CAS No.:194299-30-4
Molecular Formula:C₆₆H₉₇NO₁₂
Molecular Weight:1096.5
Hs Code.:

Synonyms:(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

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Chemical Property of (2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

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Technology Process of (2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

There total 11 articles about (2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103348-50-1
(2S,3R,4E)-2-azido-3-benzoyloxy-4-octadecen-1-ol

: 194299-30-4
(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / SnCl₄, 4 Angstroem molecular sieves / CH₂Cl₂; hexane / 1 h

2: NaOMe / methanol / Ambient temperature

3: HCOOH / 0.75 h / 22 °C

4: pyridine / 5 °C

5: 88 percent / aq. TFA / CH₂Cl₂ / 3 h / 22 °C

6: 53 percent / 4-(dimethylamino)pyridine / 22 °C

7: H₂S, pyridine / H₂O / 18 h / 22 °C

8: NaOAc, water / tetrahydrofuran

With pyridine; dmap; formic acid; 4 A molecular sieve; hydrogen sulfide; water; sodium methylate; sodium acetate; tin(IV) chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/jm9606960

Reference yield:

: 86520-63-0
2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate

: 194299-30-4
(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / SnCl₄, 4 Angstroem molecular sieves / CH₂Cl₂; hexane / 1 h

2: NaOMe / methanol / Ambient temperature

3: HCOOH / 0.75 h / 22 °C

4: pyridine / 5 °C

5: 88 percent / aq. TFA / CH₂Cl₂ / 3 h / 22 °C

6: 53 percent / 4-(dimethylamino)pyridine / 22 °C

7: H₂S, pyridine / H₂O / 18 h / 22 °C

8: NaOAc, water / tetrahydrofuran

With pyridine; dmap; formic acid; 4 A molecular sieve; hydrogen sulfide; water; sodium methylate; sodium acetate; tin(IV) chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1021/jm9606960

Reference yield:

: 118711-43-6
(2S,3R,4E)-2-azido-3-(benzoyloxy)-1-[(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)oxy]-4-octadecene

: 194299-30-4
(2S,3R,4E)-2-(hexadecanoylamino)-3-(benzoyloxy)-1-[(2,3-di-O-benzoyl-6-O-pivaloyl-β-D-galactopyranosyl)oxy]-4-octadecene

Guidance literature:: Multi-step reaction with 7 steps

1: NaOMe / methanol / Ambient temperature

2: HCOOH / 0.75 h / 22 °C

3: pyridine / 5 °C

4: 88 percent / aq. TFA / CH₂Cl₂ / 3 h / 22 °C

5: 53 percent / 4-(dimethylamino)pyridine / 22 °C

6: H₂S, pyridine / H₂O / 18 h / 22 °C

7: NaOAc, water / tetrahydrofuran

With pyridine; dmap; formic acid; hydrogen sulfide; water; sodium methylate; sodium acetate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm9606960