N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

Base Information

Chemical Name:N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide
CAS No.:676631-81-5
Molecular Formula:C₂₈H₄₅N₃O₄
Molecular Weight:487.683
Hs Code.:

Synonyms:N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

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Chemical Property of N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

Chemical Property:

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Technology Process of N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

There total 4 articles about N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 544-97-8
dimethyl zinc(II)

: (S,E)-4-((S)-2-((S)-3-(3-bromophenyl)-3-methyl-2-(methylamino)butanamide)-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoic acid

: 676631-81-5
N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃; for 2.5h;

Reference yield:

: 676631-78-0
(E)-(S)-4-{[(S)-3,3-Dimethyl-2-((S)-3-methyl-2-methylamino-3-m-tolyl-butyrylamino)-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid ethyl ester

: 676631-81-5
N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2004.08.024

Reference yield:

: 3-methyl-2-methylimino-3-m-tolyl-butyric acid

: 676631-81-5
N,β,β,3-tetramethyl-L-phenylalanyl-N1-[(1S,2E)-3-carboxy-1-isopropyl-2-butenyl]-N1,3-dimethyl-L-valinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: BH₃*pyridine / 4 h / 60 °C

2.1: hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; N-methylmorpholine / dimethylformamide / 0 - 20 °C

2.2: dimethylformamide / 20 °C

3.1: aq. LiOH / methanol / 15 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; borane pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.024