N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

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Chemical Name:N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide
CAS No.:1437870-64-8
Molecular Formula:C₂₁H₂₄ClN₇O₄
Molecular Weight:473.919
Hs Code.:

Synonyms:N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

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Chemical Property of N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

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Technology Process of N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

There total 10 articles about N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660851-49-0
(5-cyano-pyrazin-2-yl)-carbamic acid phenyl ester

: 1437718-00-7
N-[2-(4-amino-2-chloro-5-methoxy-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

: 1437870-64-8
N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 90 ℃; for 1.5h;

Reference yield:

: 1027833-17-5
1-bromo-2-chloro-5-fluoro-4-nitrobenzene

: 1437870-64-8
N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

3: quinoline / isopropyl alcohol / 20 h / 70 °C

4: water; ammonium cerium (IV) nitrate / acetonitrile / 2.5 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: potassium carbonate / acetonitrile / 8 h / 70 °C

7: zinc; ammonium chloride / methanol / 6 h / 50 °C

8: N,N-dimethyl-formamide / 1.5 h / 90 °C

With quinoline; ammonium cerium (IV) nitrate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; ammonium chloride; triethylamine; zinc; In methanol; propan-1-ol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 201849-15-2
2-bromo-1-chloro-4-fluoro-benzene

: 1437870-64-8
N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium nitrate; sulfuric acid / -5 °C / Cooling with ice

2: 0 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

4: quinoline / isopropyl alcohol / 20 h / 70 °C

5: water; ammonium cerium (IV) nitrate / acetonitrile / 2.5 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: potassium carbonate / acetonitrile / 8 h / 70 °C

8: zinc; ammonium chloride / methanol / 6 h / 50 °C

9: N,N-dimethyl-formamide / 1.5 h / 90 °C

With quinoline; ammonium cerium (IV) nitrate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; water; potassium carbonate; ammonium chloride; potassium nitrate; triethylamine; zinc; In methanol; propan-1-ol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;