(2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester

Base Information

• Chemical Name: (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester
• CAS No.: 399041-12-4
• Molecular Formula: C₂₅H₃₉NO₅
• Molecular Weight: 433.588
• Mol file: 399041-12-4.mol

Synonyms:(2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester

Chemical Property of (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester

There total 6 articles about (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester (399041-12-4)

Guidance literature:

Reference yield:

ethyl N-dodecanoyl-α-imino ester + [1-(4-methoxyphenyl)vinyl]carbamic acid benzyl ester (697301-72-7) → (2S)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester + (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester (399041-12-4)

Guidance literature:

ethyl N-dodecanoyl-α-imino ester; [1-(4-methoxyphenyl)vinyl]carbamic acid benzyl ester; With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 0 ℃;

With hydrogen bromide; In methanol; water; Title compound not separated from byproducts;

DOI:10.1002/anie.200353237

Reference yield:

chloro-dodecanoylamino-acetic acid ethyl ester (503838-77-5) → (2R)-2-dodecanoylamino-4-oxo-4-(4-methoxyphenyl)butyric acid ethyl ester (399041-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (S,S)-1,2-Ph₂-N,N'-(1-naphthylmethyl)-1,2-diaminoethane / Cu(OTf)2 / CH₂Cl₂ / 18 h / 0 °C

With (S,S)-1,2-Ph₂-N,N'-bis(1-naphthylmethyl)-1,2-diaminoethane; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; 2: Mannich-type reaction;

DOI:10.1021/ol017062u

upstream raw materials:

[1-(4-methoxyphenyl)vinyl]carbamic acid benzyl ester

chloro-dodecanoylamino-acetic acid ethyl ester

Downstream raw materials:

(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester