(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

Base Information

Chemical Name:(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester
CAS No.:503840-01-5
Molecular Formula:C₂₆H₄₁NO₅
Molecular Weight:447.615
Hs Code.:

Synonyms:(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

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Chemical Property of (R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

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Technology Process of (R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

There total 5 articles about (R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-dodecanoyl-hydroxyglycine ethyl ester

: 503840-01-5
(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / CH₂Cl₂ / 1 °C / Heating

2: piperidinomethyl polystyrene / CH₂Cl₂ / 0.17 h / 20 °C / Heating

3: Cu(OTf)2; (R,R)-(1-Nap)CH₂NHPhCH-CHPhNHCH₂(1-Nap) / CH₂Cl₂ / 18 h / 0 °C

4: LHMDS

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; thionyl chloride; piperidinomethyl polystyrene; copper(II) bis(trifluoromethanesulfonate); lithium hexamethyldisilazane; In dichloromethane; 3: Mannich-type reaction;
DOI:10.1021/ja0281840

Reference yield:

: N-dodecanoyl-chloroglycine ethyl ester

: 503840-01-5
(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: piperidinomethyl polystyrene / CH₂Cl₂ / 0.17 h / 20 °C / Heating

2: Cu(OTf)2; (R,R)-(1-Nap)CH₂NHPhCH-CHPhNHCH₂(1-Nap) / CH₂Cl₂ / 18 h / 0 °C

3: LHMDS

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; piperidinomethyl polystyrene; copper(II) bis(trifluoromethanesulfonate); lithium hexamethyldisilazane; In dichloromethane; 2: Mannich-type reaction;
DOI:10.1021/ja0281840

Reference yield:

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 503840-01-5
(R)-2-Dodecanoylamino-4-(4-methoxy-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Cu(OTf)2; (R,R)-(1-Nap)CH₂NHPhCH-CHPhNHCH₂(1-Nap) / CH₂Cl₂ / 18 h / 0 °C

2: LHMDS

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); lithium hexamethyldisilazane; In dichloromethane; 1: Mannich-type reaction;
DOI:10.1021/ja0281840