2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

Base Information

Chemical Name:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid
CAS No.:1374118-87-2
Molecular Formula:C₃₂H₃₉NO₉
Molecular Weight:581.663
Hs Code.:

Synonyms:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Chemical Property of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Technology Process of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

There total 5 articles about 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1374119-28-4
C₃₆H₄₇NO₉

: 1374118-87-2
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm201746x

Reference yield:

: 178445-83-5
3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)-1-propanone

: 1374118-87-2
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 20 h / 20 °C

2: Noyori catalyst (ABCR AB₁₃₁₆₀₀); hydrogen; potassium carbonate / isopropyl alcohol / 144 h / 20 °C / 11251.1 Torr

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With dmap; Noyori catalyst (ABCR AB₁₃₁₆₀₀); hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol; acetone;
DOI:10.1021/jm201746x

Reference yield:

: 178445-86-8
2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester

: 1374118-87-2
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)-1,2,3,6-tetrahydropyridine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Noyori catalyst (ABCR AB₁₃₁₆₀₀); hydrogen; potassium carbonate / isopropyl alcohol / 144 h / 20 °C / 11251.1 Torr

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With dmap; Noyori catalyst (ABCR AB₁₃₁₆₀₀); hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm201746x