tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Base Information

• Chemical Name: tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane
• CAS No.: 199471-99-3
• Molecular Formula: C₃₅H₄₀O₄SSi
• Molecular Weight: 584.852

Synonyms:tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Chemical Property of tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

There total 10 articles about tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

thiophenol (108-98-5) + Acetic acid (4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl ester (199472-32-7) → tert-Butyl-[(2S,3S,5R)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane (199471-97-1) + tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane (199471-99-3)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1055/s-1997-1033

Reference yield:

[3-(2-Benzyloxyethyl)oxiran-2-yl]methanol (89956-14-9) → tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane (199471-99-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 82 percent / Ti(Oi-Pr)4 / toluene / 1 h / 100 °C

2: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: 97 percent / DMAP, Et₃N / CH₂Cl₂ / 1 h / 20 °C

4: 80 percent / toluene / 48 h / Heating

5: 95 percent / H₂ / Ra-Ni (W₂) / ethanol / 24 h / 20 °C

6: 95 percent / K₂CO₃ / methanol / 1 h / 20 °C

7: 69 percent / o-idoxybenzoic acid, DMSO / tetrahydrofuran / 2 h / 20 °C

8: 92 percent / DMAP, Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

9: 45 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / -78 °C

With titanium(IV) isopropylate; dmap; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; Ra-Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1055/s-1997-1033

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane (199471-99-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 82 percent / Ti(Oi-Pr)4 / toluene / 1 h / 100 °C

2: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: 97 percent / DMAP, Et₃N / CH₂Cl₂ / 1 h / 20 °C

4: 80 percent / toluene / 48 h / Heating

5: 95 percent / H₂ / Ra-Ni (W₂) / ethanol / 24 h / 20 °C

6: 95 percent / K₂CO₃ / methanol / 1 h / 20 °C

7: 69 percent / o-idoxybenzoic acid, DMSO / tetrahydrofuran / 2 h / 20 °C

8: 92 percent / DMAP, Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

9: 45 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / -78 °C

With titanium(IV) isopropylate; dmap; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; Ra-Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1055/s-1997-1033

upstream raw materials:

thiophenol

Acetic acid (4S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl ester

[3-(2-Benzyloxyethyl)oxiran-2-yl]methanol

4-Methoxybenzyl alcohol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 199471-99-3 tert-Butyl-[(2S,3S,5S)-3-(4-methoxy-benzyloxy)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane

Send

Send

Metric Ton KG G Pound L ML

Send

Send