ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

Base Information

Chemical Name:ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate
CAS No.:1415130-74-3
Molecular Formula:C₃₁H₂₉ClFN₃O₃
Molecular Weight:546.041
Hs Code.:

Synonyms:ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

There total 6 articles about ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415130-73-2
N-(1-(2-bromo-4-chlorophenyl)ethyl)-4'-fluoro-[1,1'-biphenyl]-4-amine

: 1415129-85-9
ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate

: 1415130-74-3
ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

Guidance literature:: With potassium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In water; N,N-dimethyl-formamide; at 90 ℃; for 16h;

Reference yield:

: 825-40-1
2-bromo-p-chloroacetophenone

: 1415130-74-3
ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide; water / 16 h / 90 °C

With methanol; sodium tetrahydroborate; potassium carbonate; methanesulfonyl chloride; triethylamine; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1086601-87-7
1-(2-bromo-4-chlorophenyl)ethanol

: 1415130-74-3
ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide; water / 16 h / 90 °C

With potassium carbonate; methanesulfonyl chloride; triethylamine; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In dichloromethane; water; N,N-dimethyl-formamide;