6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester

Base Information

• Chemical Name: 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester
• CAS No.: 766548-72-5
• Molecular Formula: C₂₇H₃₁NO₃
• Molecular Weight: 417.548
• Mol file: 766548-72-5.mol

Synonyms:6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester

Chemical Property of 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester

There total 1 articles about 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 6-aminocaproate hydrochloride (1926-80-3) + mono-4-methoxytrityl chloride (14470-28-1) → 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester (766548-72-5)

Guidance literature:

With TEA; In dichloromethane;

DOI:10.1016/j.bmcl.2004.06.055

Reference yield: 75.0%

6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester (766548-72-5) → 6-hexanoic acid (135672-64-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.06.055

Reference yield:

6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester (766548-72-5) → 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid (766548-79-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / aq. LiOH / tetrahydrofuran

2: Bop; DIPEA / dimethylformamide

3: aq. LiOH; CaCl₂ / propan-2-ol

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; calcium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2004.06.055

upstream raw materials:

methyl 6-aminocaproate hydrochloride

mono-4-methoxytrityl chloride

Downstream raw materials:

6-hexanoic acid

6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid