6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid

Base Information

• Chemical Name: 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid
• CAS No.: 766548-79-2
• Molecular Formula: C₄₈H₆₄N₄O₇
• Molecular Weight: 809.059
• Mol file: 766548-79-2.mol

Synonyms:6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid

Chemical Property of 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid

There total 6 articles about 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-aminocaproate hydrochloride (1926-80-3) → 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid (766548-79-2)

Guidance literature:

Multi-step reaction with 4 steps

1: Bop; DIPEA / dimethylformamide

2: 93 percent / AcCl; MeOH

3: Bop; DIPEA / dimethylformamide

4: aq. LiOH; CaCl₂ / propan-2-ol

With methanol; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; acetyl chloride; calcium chloride; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2004.06.055

Reference yield:

6-hexanoic acid (135672-64-9) → 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid (766548-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Bop; DIPEA / dimethylformamide

2: aq. LiOH; CaCl₂ / propan-2-ol

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; calcium chloride; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2004.06.055

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 6-[(S)-6-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-hexanoylamino]-hexanoic acid (766548-79-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / TEA / CH₂Cl₂

2: 75 percent / aq. LiOH / tetrahydrofuran

3: Bop; DIPEA / dimethylformamide

4: aq. LiOH; CaCl₂ / propan-2-ol

With lithium hydroxide; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; calcium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2004.06.055

upstream raw materials:

methyl 6-aminocaproate hydrochloride

6-hexanoic acid

mono-4-methoxytrityl chloride

6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester