Sch 60672

Base Information

• Chemical Name: Sch 60672
• CAS No.: 253682-77-8
• Molecular Formula: C₂₄H₂₀FN₃O₃S
• Molecular Weight: 449.506
• Mol file: 253682-77-8.mol

Synonyms:Sch 60672

Chemical Property of Sch 60672

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sch 60672

There total 4 articles about Sch 60672 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3R,4S)-1-Benzo[1,2,5]thiadiazol-4-yl-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-[4-(4-methoxy-benzyloxy)-phenyl]-azetidin-2-one → Sch 60672 (253682-77-8)

Guidance literature:

With boron trichloride; In dichloromethane;

DOI:10.1016/S0960-894X(01)00752-1

Reference yield:

Benzo[1,2,5]thiadiazol-4-yl-[1-[4-(4-methoxy-benzyloxy)-phenyl]-meth-(E)-ylidene]-amine → Sch 60672 (253682-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TiCl₄; iPr₂NEt / CH₂Cl₂

1.2: BSA / toluene

1.3: TBAF

2.1: 36 percent / aq. MeOH; Et₃N

3.1: 89 percent / BCl₃ / CH₂Cl₂

With methanol; boron trichloride; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00752-1

Reference yield:

(S)-1-(4-fluorophenyl)-5-oxo-5-[(S)-2-oxo-4-phenyloxazolidin-3-yl]pentyl acetate → Sch 60672 (253682-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TiCl₄; iPr₂NEt / CH₂Cl₂

1.2: BSA / toluene

1.3: TBAF

2.1: 36 percent / aq. MeOH; Et₃N

3.1: 89 percent / BCl₃ / CH₂Cl₂

With methanol; boron trichloride; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00752-1

upstream raw materials:

Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester