Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester

Base Information

• Chemical Name: Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester
• CAS No.: 433953-62-9
• Molecular Formula: C₃₄H₃₀FN₃O₅S
• Molecular Weight: 611.694
• Mol file: 433953-62-9.mol

Synonyms:

Chemical Property of Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester

There total 1 articles about Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzo[1,2,5]thiadiazol-4-yl-[1-[4-(4-methoxy-benzyloxy)-phenyl]-meth-(E)-ylidene]-amine + (S)-1-(4-fluorophenyl)-5-oxo-5-[(S)-2-oxo-4-phenyloxazolidin-3-yl]pentyl acetate → Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester (433953-62-9)

Guidance literature:

Benzo[1,2,5]thiadiazol-4-yl-[1-[4-(4-methoxy-benzyloxy)-phenyl]-meth-(E)-ylidene]-amine; (S)-1-(4-fluorophenyl)-5-oxo-5-[(S)-2-oxo-4-phenyloxazolidin-3-yl]pentyl acetate; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

With benzenesulfonamide; In toluene;

With tetrabutyl ammonium fluoride;

DOI:10.1016/S0960-894X(01)00752-1

Reference yield: 36.0%

Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester (433953-62-9) → (3R,4S)-1-Benzo[1,2,5]thiadiazol-4-yl-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-[4-(4-methoxy-benzyloxy)-phenyl]-azetidin-2-one

Guidance literature:

With methanol; triethylamine;

DOI:10.1016/S0960-894X(01)00752-1

Reference yield:

Acetic acid (S)-3-{(2S,3R)-1-benzo[1,2,5]thiadiazol-4-yl-2-[4-(4-methoxy-benzyloxy)-phenyl]-4-oxo-azetidin-3-yl}-1-(4-fluoro-phenyl)-propyl ester (433953-62-9) → Sch 60672 (253682-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / aq. MeOH; Et₃N

2: 89 percent / BCl₃ / CH₂Cl₂

With methanol; boron trichloride; triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00752-1

Downstream raw materials:

Sch 60672