(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Base Information

Chemical Name:(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate
CAS No.:1312692-15-1
Molecular Formula:C₂₅H₃₃N₅O₅
Molecular Weight:483.568
Hs Code.:

Synonyms:(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

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Chemical Property of (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

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Technology Process of (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

There total 10 articles about (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312690-83-7
methyl 6-chloro-4-cyano-2-(m-tolylamino)nicotinate

: 1312692-11-7
(R)-tert-butyl 1-amino-3-ethoxypropan-2-ylcarbamate

: 1312692-15-1
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 65 ℃; for 1h;

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1312692-15-1
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride; methanol / tetrahydrofuran / 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -15 °C

2.2: 0.5 h / -15 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 75 °C

5.1: hydrogen / palladium on carbon / methanol / 20 °C / 760.05 Torr

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 65 °C

With 4-methyl-morpholine; methanol; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 104839-00-1
N-(tert-butoxycarbonyl)-O-ethylserine

: 1312692-15-1
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -15 °C

1.2: 0.5 h / -15 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 75 °C

4.1: hydrogen / palladium on carbon / methanol / 20 °C / 760.05 Torr

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 65 °C

With 4-methyl-morpholine; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;