Technology Process of (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate
There total 10 articles about (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-ethoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 65 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride; methanol / tetrahydrofuran / 20 °C
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -15 °C
2.2: 0.5 h / -15 °C
3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 75 °C
5.1: hydrogen / palladium on carbon / methanol / 20 °C / 760.05 Torr
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 65 °C
With
4-methyl-morpholine; methanol; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
palladium on carbon;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -15 °C
1.2: 0.5 h / -15 °C
2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 4 h / 75 °C
4.1: hydrogen / palladium on carbon / methanol / 20 °C / 760.05 Torr
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 65 °C
With
4-methyl-morpholine; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
palladium on carbon;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;