6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

Base Information

Chemical Name:6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline
CAS No.:1266118-04-0
Molecular Formula:C₂₁H₂₆F₃NO
Molecular Weight:365.439
Hs Code.:

Synonyms:6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

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Chemical Property of 6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

Chemical Property:

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Technology Process of 6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

There total 3 articles about 6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266118-03-9
2-methyl-4-trifluoromethyl-quinolin-6-ol

: 1266118-04-0
6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 72h;

Reference yield:

: 1042738-26-0
6-methoxy-2-methyl-4-(trifluoromethyl)quinoline

: 1266118-04-0
6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 22 h / -78 - 23 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 72 h / 20 °C

With di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In dichloromethane; toluene; 2: Mitsunobu reaction;

Reference yield:

: 856095-00-6
4-bromo-6-methoxy-2-methylquinoline

: 1266118-04-0
6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 18 h / 55 - 80 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 22 h / -78 - 23 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 72 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;