856095-00-6

Basic information

• Product Name: 4-BROMO-6-METHOXY-2-METHYLQUINOLINE
• Synonyms: 4-BROMO-6-METHOXY-2-METHYLQUINOLINE;4-BROMO-6-METHOXYQUINALDINE
• CAS NO: 856095-00-6
• Molecular Formula: C₁₁H₁₀BrNO
• Molecular Weight: 252.11
• Mol File: 856095-00-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 341.3°C at 760 mmHg
• Flash Point: 160.2°C
• Appearance: /
• Density: 1.455g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.22±0.50(Predicted)
• CAS DataBase Reference: 4-BROMO-6-METHOXY-2-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-6-METHOXY-2-METHYLQUINOLINE(856095-00-6)
• EPA Substance Registry System: 4-BROMO-6-METHOXY-2-METHYLQUINOLINE(856095-00-6)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 856095-00-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-6-methoxy-2-methylquinoline is a chemical compound with the molecular formula C11H10BrNO. It is a quinoline derivative that contains a bromo and a methoxy group on its structure. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also shown potential in medicinal chemistry due to its biological activities, such as antifungal and antibacterial properties. Additionally, this compound has been studied for its potential as a fluorescent probe for metal ions. Overall, 4-Bromo-6-methoxy-2-methylquinoline is a versatile chemical that has diverse applications in various fields of research and industry.

InChI:InChI=1/C11H10BrNO/c1-7-5-10(12)9-6-8(14-2)3-4-11(9)13-7/h3-6H,1-2H3

Upstream product

• 15644-90-3 6-methoxy-2-methylquinolin-4-ol 
• 104-94-9 4-methoxy-aniline 
• 33240-23-2 ethyl (Z)-3-(4-methoxyanilino)-2-butenoate 

Downstream Products

• 872273-59-1 [2-(6-methoxy-2-methyl-[4]quinolylamino)-phenyl]-arsonic acid 
• 856095-15-3 N-(4-(4-aminobenzyl)phenyl)-6-methoxy-2-methylquinolin-4-amine 
• 1078-28-0 6-methoxyquinaldine 
• 89060-22-0 6-methoxyquinoline-2-carboxaldehyde 
• 1266118-11-9 1-[6-(trans-4-tert-butyl-cyclohexyloxy)-4-trifluoromethyl-quinolin-2-ylmethyl]-azetidine-3-carboxylic acid 
• 1266118-10-8 1-[6-(trans-4-tert-butyl-cyclohexyloxy)-4-trifluoromethyl-quinolin-2-ylmethyl]-azetidine-3-carboxylic acid methyl ester 
• 1266118-06-2 6-(trans-4-tert-butyl-cyclohexyloxy)-4-trifluoromethyl-quinoline-2-carbaldehyde 
• 1266118-04-0 6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline 
• 1042738-26-0 6-methoxy-2-methyl-4-(trifluoromethyl)quinoline 

Relevant articles and documents

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides

In this study, a new series of more than 60 quinoline derivatives has been synthesized and evaluated against Mycobacterium tuberculosis (H37Rv). Apart from the SAR exploration around the initial hits, the optimization process focused on the improvement of the physicochemical properties, cytotoxicity, and metabolic stability of the series. The best compounds obtained exhibited MIC values in the low micromolar range, excellent intracellular antimycobacterial activity, and an improved physicochemical profile without cytotoxic effects. Further investigation revealed that the amide bond was the source for the poor blood stability observed, while some of the compounds exhibited hERG affinity. Compound 83 which contains a benzoxazole ring instead of the amide group was found to be a good alternative, with good blood stability and no hERG affinity, providing new opportunities for the series. Overall, the obtained results suggest that further optimization of solubility and microsomal stability of the series could provide a strong lead for a new anti-TB drug development program.