4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

Base Information

Chemical Name:4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide
CAS No.:1036742-48-9
Molecular Formula:C₂₀H₃₁N₇O₃
Molecular Weight:417.511
Hs Code.:

Synonyms:4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

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Chemical Property of 4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

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Technology Process of 4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

There total 6 articles about 4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1036742-51-4
7-(4-((1-((3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)benzamido)heptanoic acid methyl ester

: 1036742-48-9
4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

Guidance literature:: With potassium cyanide; hydroxylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2008.04.007

Reference yield:

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 1036742-48-9
4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide; toluene / 50 °C / Inert atmosphere

4.1: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(actonitrile)copper(I) hexafluorophosphate / acetonitrile / 16 h / 60 °C / Inert atmosphere

5.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere

With 4-methyl-morpholine; potassium cyanide; tetrakis(actonitrile)copper(I) hexafluorophosphate; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate; isobutyl chloroformate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00471

Reference yield:

: 1036742-52-5
7-(4-nitrobenzoylamino)-heptanoic acid methyl ester

: 1036742-48-9
4-(((1-(3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide; toluene / 50 °C / Inert atmosphere

3: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(actonitrile)copper(I) hexafluorophosphate / acetonitrile / 16 h / 60 °C / Inert atmosphere

4: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 20 °C / Inert atmosphere

With potassium cyanide; tetrakis(actonitrile)copper(I) hexafluorophosphate; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00471