Technology Process of 7-(4-((1-((3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)benzamido)heptanoic acid methyl ester
There total 5 articles about 7-(4-((1-((3-aminopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)benzamido)heptanoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(acetonitrile)copper(I)hexafluorophosphate; tris-(1-benzyl-1H-1,2,3-triazol-4-ylmethyl)amine;
In
acetonitrile;
at 60 ℃;
for 16h;
DOI:10.1016/j.bmcl.2008.04.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide; toluene / 50 °C / Inert atmosphere
4.1: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(actonitrile)copper(I) hexafluorophosphate / acetonitrile / 16 h / 60 °C / Inert atmosphere
With
4-methyl-morpholine; tetrakis(actonitrile)copper(I) hexafluorophosphate; palladium 10% on activated carbon; hydrogen; potassium carbonate; isobutyl chloroformate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00471
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide; toluene / 50 °C / Inert atmosphere
3: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(actonitrile)copper(I) hexafluorophosphate / acetonitrile / 16 h / 60 °C / Inert atmosphere
With
tetrakis(actonitrile)copper(I) hexafluorophosphate; palladium 10% on activated carbon; hydrogen; potassium carbonate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine;
In
methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00471