ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate
CAS No.:1309567-88-1
Molecular Formula:C₂₉H₃₇NO₇Si
Molecular Weight:539.701
Hs Code.:

Synonyms:ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

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Chemical Property of ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

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Technology Process of ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

There total 6 articles about ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 156635-90-4
[4-[(4-methoxyphenyl)methoxy]phenyl]boronic acid

: 1309567-86-9
ethyl 5-bromo-4-methoxy-2-oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

: 1309567-88-1
ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; at 60 ℃; for 16h;
DOI:10.1039/c2md20181j

Reference yield:

: 156635-90-4
[4-[(4-methoxyphenyl)methoxy]phenyl]boronic acid

: 1309567-73-4
ethyl 5-bromo-4-methoxy-2-oxo-1,2-dihydropyridine-3-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1309567-89-2
ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-((2-(trimethylsilyl)ethoxy)methoxy)nicotinate

: 1309567-88-1
ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: ethyl 5-bromo-4-methoxy-2-oxo-1,2-dihydropyridine-3-carboxylate; (2-trimethylethylsilylethoxy)methyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

[4-[(4-methoxyphenyl)methoxy]phenyl]boronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; at 60 ℃; for 16h;
DOI:10.1002/anie.201007671

Reference yield:

: ethyl 2-cyano-5-(dimethylamino)-3-methoxypenta-2,4-dienoate

: 1309567-88-1
ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water / Reflux

2.1: N-Bromosuccinimide / -18 °C / Reflux; Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 16 h / 60 °C

With N-Bromosuccinimide; acetic acid; triethylamine; In dichloromethane; water;
DOI:10.1002/anie.201007671