dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

Base Information

Chemical Name:dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate
CAS No.:1309567-75-6
Molecular Formula:C₂₄H₂₆NO₈P
Molecular Weight:487.446
Hs Code.:

Synonyms:dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

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Chemical Property of dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

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Technology Process of dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

There total 7 articles about dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1309567-74-5
ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 756-79-6
dimethyl methane phosphonate

: 1309567-75-6
dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 0.25h; Inert atmosphere;

ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1002/anie.201007671

Reference yield:

: 1309567-73-4
ethyl 5-bromo-4-methoxy-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1309567-75-6
dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 16 h / 60 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 60 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - -20 °C / Inert atmosphere

3.2: 0.17 h / -78 - 0 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/anie.201007671

Reference yield:

: 87853-84-7
ethyl 2-cyano-3-methoxybut-2-enoate

: 1309567-75-6
dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 0.75 h / 130 °C / Inert atmosphere

2.1: acetic acid / water / Reflux

3.1: N-Bromosuccinimide / -18 °C / Reflux; Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: 16 h / 60 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 60 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - -20 °C / Inert atmosphere

6.2: 0.17 h / -78 - 0 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1002/anie.201007671