3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

Base Information

Chemical Name:3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one
CAS No.:1044870-23-6
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Synonyms:3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

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Chemical Property of 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

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Technology Process of 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

There total 6 articles about 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 884502-04-9
2,4-dimethoxy-N,6-dimethylbenzamide

: 924300-43-6
4-(tert-butyldimethylsilanyloxy)-3,5-dimethylbenzonitrile

: 1044870-24-7
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinoline-1(2H)-one

: 1044870-23-6
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

Guidance literature:: 2,4-dimethoxy-N,6-dimethylbenzamide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

4-(tert-butyldimethylsilanyloxy)-3,5-dimethylbenzonitrile; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 16h;

With hydrogenchloride; In ethanol; water; at 80 ℃; for 2h;

Reference yield: 5.0%

: 1044872-78-7
C₂₅H₃₃NO₄Si

: 1044871-96-6
C₂₆H₃₅NO₄Si

: 1044870-24-7
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinoline-1(2H)-one

: 1044870-23-6
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

Guidance literature:: C₂₅H₃₃NO₄Si; C₂₆H₃₅NO₄Si; With hydrogenchloride; water; In ethanol; at 80 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 3686-57-5
2,4-dimethoxy-6-methylbenzoic acid

: 1044870-24-7
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinoline-1(2H)-one

: 1044870-23-6
3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 16 h / 20 °C

1.2: 4 h / 20 °C / Cooling

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 16 h / -50 - 20 °C

2.3: 2 h / 80 °C

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; dichloromethane;