884502-04-9

Upstream product

• 55018-89-8 2,4-dimethoxy-6-methylbenzoyl chloride 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 

Downstream Products

• 1044870-24-7 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinoline-1(2H)-one 
• 1044870-23-6 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2-methyl-isoquinoline-1(2H)-one 
• 1044872-78-7 C₂₅H₃₃NO₄Si 
• 1044871-96-6 C₂₆H₃₅NO₄Si 
• 924300-40-3 3-{4-[2-[(tert-butyl dimethylsilyl)oxy]-2-methylpropoxy]-3,5-dimethylphenyl}-6,8-dimethoxy-2H-isoquinolin-1-one 
• 884502-08-3 C₂₃H₂₉NO₄Si 

Relevant academic research and scientific papers

Used for the prevention and treatment of cardiovascular diseases

The invention relates to compounds that can be used for adjusting the expression of apolipoprotein A-I (ApoA-I) and usage of the compounds in treating and preventing cardiovascular diseases and related diseases, including the disorder related to cholesterol or lipids such as atherosclerosis.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of cancer, including NUT midline carcinoma, Burkitt's Lymphoma, Acute Myelogenous Leukemia, and Multiple Myeloma; autoimmune or inflammatory diseases or conditions, and sepsis.

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotei? A-I (ApoA-l), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF COMPLEX DISEASES AND THEIR DELIVERY BY INSERTABLE MEDICAL DEVICES

The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.